Ferroptosis-related lncRNAs signature to predict the survival and immune evasion for lung squamous cell carcinoma.

ABSTRACT: Introduction: the investigation on the interactions between ferroptosis and lncRNAs for lung squamous cell carcinoma (LUSC) has been scare, and its impact on tumor immune microenvironment remained unknown. We aim to not only identify a ferroptosis-related lncRNAs signature for LUSC prognosis, but also evaluate its correlation to tumor immune evasion. Methods: RNA sequencing data and survival information were obtained from The Cancer Genome Atlas database. A ferroptosis-related lncRNAs signature (FerRLSig) was developed and validated by univariate Cox regression, Least Absolute Shrinkage and Selection Operator regression and multivariate Cox regression. The tumor immune microenvironment and immune evasion were subsequently evaluated based on the FerRLSig stratification. Res

SUBMITTER: Zhang R 

PROVIDER: S-EPMC9459014 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature