Transcriptome profiles of latently- and reactivated HIV-1 infected primary CD4⁺ T cells: A pooled data-analysis.

ABSTRACT: The main obstacle to cure HIV-1 is the latent reservoir. Antiretroviral therapy effectively controls viral replication, however, it does not eradicate the latent reservoir. Latent CD4⁺ T cells are extremely rare in HIV-1 infected patients, making primary CD4⁺ T cell models of HIV-1 latency key to understanding latency and thus finding a cure. In recent years several primary CD4⁺ T cell models of HIV-1 latency were developed to study the underlying mechanism of establishing, maintaining and reversing HIV-1 latency. In the search of biomarkers, primary CD4⁺ T cell models of HIV-1 latency were used for bulk and single-cell transcriptomics. A wealth of information was generated from transcriptome analyses of different primary CD4⁺ T cell m

SUBMITTER: Inderbitzin A 

PROVIDER: S-EPMC9459035 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature