Differential distribution and prognostic value of CD4⁺ T cell subsets before and after radioactive iodine therapy in differentiated thyroid cancer with varied curative outcomes.

ABSTRACT: Differentiated thyroid cancer is the most frequently diagnosed endocrine tumor. While differentiated thyroid cancers often respond to initial treatment, little is known about the differences in circulating immune cells amongst patients who respond differently. A prospective study of 39 patients with differentiated thyroid cancer was conducted. Serum thyroglobulin levels and thyroid and immunological functions were tested before and after radioactive iodine treatment (RAIT). Efficacy assessments were performed 6 to 12 months after radioactive iodine treatment. Most patients showed an excellent response to radioactive iodine treatment. Before radioactive iodine treatment, the excellent response group had considerably fewer circulating CD4⁺ T cell subsets than the non-excellent res

SUBMITTER: Shi ZY 

PROVIDER: S-EPMC9459039 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature