Liver transcriptomics reveals features of the host response in a mouse model of dengue virus infection.

ABSTRACT:

Background

Dengue virus (DENV) infection induces various clinical manifestations and even causes organ injuries, leading to severe dengue haemorrhagic fever and dengue shock syndrome. Hepatic dysfunction was identified as a risk predictor of progression to severe disease during the febrile phase of dengue. However, the underlying mechanisms of hepatic injury remain unclear.

Methods

A model of dengue disease was established in IFNAR ^-/- C57BL/6 mice by challenge with DENV-2. Body weight, symptoms, haematological parameters and liver pathological observations in mice were used to determine the effects of DENV infection. Liver transcriptome sequencing was performed to evaluate the features of the host response in IFNAR ^-/- mice challenged wit

SUBMITTER: Zheng W 

PROVIDER: S-EPMC9459046 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature