Synthesis of ginsenoside Rb₁-imprinted magnetic polymer nanoparticles for the extraction and cellular delivery of therapeutic ginsenosides.

ABSTRACT:

Background

Panax ginseng (ginseng) is a traditional medicine that is reported to have cardioprotective effects; ginsenosides are the major bioactive compounds in the ginseng root.

Methods

Magnetic molecularly imprinted polymer (MMIP) nanoparticles might be useful for both the extraction of the targeted (imprinted) molecules, and for the delivery of those molecules to cells. In this work, plant growth regulators were used to enhance the adventitious rooting of ginseng root callus; imprinted polymeric particles were synthesized for the extraction of ginsenoside Rb₁ from root extracts, and then employed for subsequent particle-mediated delivery to cardiomyocytes to mitigate hypoxia/reoxygenation injury.

Results

These synthesized composite nanoparticles

SUBMITTER: Liu KH 

PROVIDER: S-EPMC9459059 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature