DNA methylation regulators-related molecular patterns and tumor immune landscape in hepatocellular carcinoma.

ABSTRACT: Increasing evidence showed that the dysregulation of DNA methylation regulators is a decisive feature of almost all cancer types and affects tumor progressions. However, few studies focused on the underlying influences of DNA methylation regulators-related genes (DMRegs) in immune cell-infiltration characteristics, tumor microenvironment (TME) and immunotherapy in HCC patients. In our study, the alterations of DNA methylation regulators modification patterns (DMRPs) were clustered from hepatocellular carcinoma (HCC) samples based on the expression of DNA methylation regulators as well as genetic and transcriptional features. In addition, based on molecular identification of three distinct molecular subtypes, we found that different DMRPs alterations were related to different clinicopatholo

SUBMITTER: Song D 

PROVIDER: S-EPMC9459088 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature