Identification of a chromatin regulator signature and potential prognostic ability for adrenocortical carcinoma.

ABSTRACT: Objective: Adrenocortical carcinoma (ACC) is a rare malignant tumor. Chromatin regulators (CRs) can drive epigenetic changes, which have been considered as one of the most vital hallmarks of tumors. This study aimed to explore the CR signature for ACC in order to clarify the molecular basis of ACC's pathogenic mechanism and provide novel methods to diagnose and treat ACC clinically. Methods: This study obtained transcriptome sequencing datasets of ACC patients and sequencing data on normal adrenal tissues in TCGA and GTEx databases, respectively. Meanwhile, prognostic genes were selected through Lasso and Cox regression analyses. Using the transcriptome sequencing datasets of ACC patients downloaded from the GEO database to finish validation, we performed Kaplan-Meier (KM) an

SUBMITTER: Li J 

PROVIDER: S-EPMC9459121 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature