Lactobacillus mucosae exerted different antiviral effects on respiratory syncytial virus infection in mice.

ABSTRACT: Respiratory syncytial virus (RSV) infection is a constant threat to the health of young children, and this is mainly attributed to the lack of effective prevention strategies. This study aimed to determine whether Lactobacillus (L.) mucosae, a potential probiotic, could protect against respiratory viral infection in a mouse model. Naive 3-4-week-old BALB/c mice were orally administered with three L. mucosae strains (2.5 × 10⁸ CFU/mouse) 7 days before RSV infection (10⁵ TCID₅₀/mouse). Results showed that all three strains inhibited RSV replication and reduced the proportions of inflammatory cells, including granulocytes and monocytes in the blood. The L. mucosae M104R01L3 treatment maintained stable weight in mice and incre

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9459143 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature