Characteristics and survival in bone metastatic breast cancer patients with different hormone receptor status: A population-based cohort study.

ABSTRACT:

Background

Accumulating preclinical evidence has uncovered the indispensable role of steroid hormone and their receptors, namely, estrogen receptor (ER) and progesterone receptor (PR), in the development of bone metastases in breast cancer. Limited data are available regarding the survival difference between different hormone receptor (HR) subgroups, and its prognostic significance is uncertain now. Such data are important for risk stratification and needed to formulate specialized regimen for bone metastatic breast cancer.

Methods

From the year of diagnosis 2010 to 2018, 554,585 breast cancer patients, among which are 19,439 with bone metastasis and 10,447 with bone-only metastasis, were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-

SUBMITTER: Jiang X 

PROVIDER: S-EPMC9459168 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature