Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure.

ABSTRACT: Microglia cells are the macrophage population within the central nervous system, which acts as the first line of the immune defense. These cells present a high level of heterogeneity among different brain regions regarding morphology, cell density, transcriptomes, and expression of different inflammatory mediators. This region-specific heterogeneity may lead to different neuroinflammatory responses, influencing the regional involvement in several neurodegenerative diseases. In this study, we aimed to evaluate microglial response in 16 brain regions. We compared different aspects of the microglial response, such as the extension of their morphological changes, sensitivity, and ability to convert an acute inflammatory response to a chronic one. Then, we investigated the synaptic alterations

SUBMITTER: Brandi E 

PROVIDER: S-EPMC9459169 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature