In vivo imaging of tau deposition in Alzheimer's disease using both [¹⁸F]-THK5317 and [¹⁸F]-S16: A pilot human study.

ABSTRACT:

Objective

To evaluate the effectiveness of a new tracer (S)-1-(4-(6-(dimethylamino)quinoxalin-2-yl)phenoxy)-3-fluoropropan-2-ol ([¹⁸F]-S16), in distinguishing patients with AD from HCs.

Methods

Paired [¹⁸F]-S16 and [¹⁸F]-THK5317 scans were acquired in five patients with AD, six HCs, one subject with a semantic variant of primary progressive aphasia (sv-PPA) and one subject with probable progressive supranuclear palsy (PSP). Dynamic PET scanning was performed over 90 min after injection of the tracers. Standardized uptake values (SUV) and cortical-to-cerebellum standardized uptake value ratios (SUVRs) were used for tau deposition semi-quantization. A voxel-based analysis was employed to assess the uptake difference between populations.<

SUBMITTER: Fu L 

PROVIDER: S-EPMC9459225 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature