Glycoprotein NMB promotes tumor formation and malignant progression of laryngeal squamous cell carcinoma.

ABSTRACT: Laryngeal squamous cell carcinoma (LSCC), although one of the most common head and neck cancers, has a static or slightly decreased survival rate because of difficulties in early diagnosis, lack of effective molecular targeting therapy, and severe dysfunction after radical surgical treatments. Therefore, a novel therapeutic target is crucial to increase treatment efficacy and survival rates in these patients. Glycoprotein NMB (GPNMB), whose role in LSCC remains elusive, is a type 1 transmembrane protein involved in malignant progression of various cancers, and its high expression is thought to be a poor prognostic factor. In this study, we showed that GPNMB expression levels in LSCC samples are significantly higher than those in normal tissues, and GPNMB expression is observed mostly in gr

SUBMITTER: Manevich L 

PROVIDER: S-EPMC9459245 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature