An insight into the diagnostic and prognostic value of HOX A13's expression in non-muscle invasive bladder cancer.

ABSTRACT:

Background

Several studies have interrogated the molecular pathways and their interacting genes underlying bladder cancer (BCa) tumorigenesis, yet, the role of homeobox genes is still poorly understood. Specifically, HOXA13, which plays an important role as a major actor in the urogenital tract's development.

Methods

Immunohistochemical (IHC) staining was performed to inspect the differential expression of HOXA13 protein in non-muscle-invasive bladder cancer (NMIBC) and non-tumoral tissues. A semiquantitative scoring system was adopted to evaluate the IHC labeling. Correlation to clinical parameters was performed by descriptive statistics. Overall survival was estimated by the Kaplan-Meier method and Cox regression model. The functional HOX A13 protein association networks (

SUBMITTER: Setti Boubaker N 

PROVIDER: S-EPMC9459288 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature