Arylsulfatase I is a prognostic biomarker for head and neck squamous cell carcinoma and Pan-cancer.

ABSTRACT:

Background

Sulfatase gene family members mediate various biological functions in tumor stroma and tumor cell environments. However, the expressions and prognostic value of Arylsulfatase I (ARSI), a sulfatase gene family member, in head and neck squamous cell carcinoma (HNSC) have not been fully established.

Methods

Arylsulfatase I expressions in pan-cancer were profiled using publicly available databases. Then, univariate Cox regression, Kaplan-Meier, and the Pearson's correlation analyses were performed to determine correlations between ARSI expressions and cancer prognosis, immune cell status, and drug sensitivity. Gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA) were used to assess the potential mechanisms underlying ARSI functions in HNSC.

Re

SUBMITTER: Shen Y 

PROVIDER: S-EPMC9459304 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature