Dynamic regional homogeneity alterations and cognitive impairment in patients with moderate and severe obstructive sleep apnea.

ABSTRACT:

Background and purpose

Previous studies have found that abnormal local spontaneous brain activity in patients with obstructive sleep apnea (OSA) was associated with cognitive impairment, and dynamic functional connections can capture the time changes of functional connections during magnetic resonance imaging acquisition. The purpose of this study was to investigate the dynamic characteristics of regional brain connectivity and its relationship with cognitive function in patients with OSA and to explore whether the dynamic changes can be used to distinguish them from healthy controls (HCs).

Methods

Seventy-nine moderate and severe male OSA patients without any treatment and 84 HCs with similar age and education were recruited, and clinical data and resting functional magneti

SUBMITTER: Li K 

PROVIDER: S-EPMC9459312 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature