Dynamic and Flexible Survival Models for Extrapolation of Relative Survival: A Case Study and Simulation Study.

ABSTRACT:

Background

Extrapolation of survival data is a key task in health technology assessments (HTAs), which may be improved by incorporating general population mortality data via relative survival models. Dynamic survival models are a promising method for extrapolation that may be expanded to dynamic relative survival models (DRSMs), a novel development presented here. There are currently neither examples of dynamic models in HTA nor comparisons of DRSMs with other relative survival models when used for survival extrapolation.

Methods

An existing appraisal, for which there had been disagreement over the approach to survival extrapolation, was chosen and the health economic model recreated. The sensitivity of estimates of cost-effectiveness to different model choices (standard sur

SUBMITTER: Kearns B 

PROVIDER: S-EPMC9459356 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature