Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver.

ABSTRACT: Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile. However, little is known about the changes in the level of transcriptional regulation. Here, we used a multi-omics approach and integrated ATAC-, RNA- and NET-seq to identify age-related changes in the chromatin landscape of murine liver and to investigate how these are linked to transcriptional regulation. We provide the first systematic inventory of the connection between aging, chromatin accessibility, and transcriptional regulation in a whole tissue. Aging in murine liver is characterized by an increase in chromatin accessibility at promoter regions, but not in an increase in transcr

SUBMITTER: Bozukova M 

PROVIDER: S-EPMC9459415 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature