Targeted therapy for pediatric diffuse intrinsic pontine glioma: a single-center experience.

ABSTRACT:

Background

Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the mainstay treatment. Several other therapeutic strategies have been attempted in the last years without a significant effect on OS. Although radiological imaging is the gold standard for DIPG diagnosis, the urgent need to improve the survival has led to the reconsideration of biopsy with the aim to better understand the molecular profile of DIPG and support personalized treatment.

Methods

In this study, we present a single-center experience in treating DIPG patients at disease progression combining targeted therapies with standard of care. Biopsy was proposed to all patients at diagnosis or diseas

SUBMITTER: Del Baldo G 

PROVIDER: S-EPMC9459464 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature