Allopurinol Use and the Risk of Type 2 Diabetes Mellitus: A Meta-Analysis of Cohort Studies.

ABSTRACT:

Objective

To assess whether there is a relation between allopurinol use and the probability of type 2 diabetes mellitus (T2DM) in persons with gout and/or hyperuricemia.

Methods

According to the PRISMA 2020 guidelines, a meta-analysis was performed by searching literature published from 2000 to 2021 in two electronic databases (Ebscohost and PubMed). The end point was set as a new diagnosis ofT2DM between people with the use of allopurinol and people with non-use of allopurinol. The random-effects model was performed to evaluate the pooled hazard ratio (HR) with 95% confidence interval (CI) for T2DM associated with allopurinol use.

Results

Three cohort studies could meet the inclusion criteria in the meta-analysis. There was a high heterogeneity of the outcome between

SUBMITTER: Lai SW 

PROVIDER: S-EPMC9459475 | biostudies-literature | 2022 Jul-Sep

REPOSITORIES: biostudies-literature