A Genome-Wide Association Study Reveals Two Genetic Markers for Chondromalacia.

ABSTRACT:

Objective

It is unknown why some athletes develop chondromalacia and others do not, even when accounting for similar workloads between individuals. Genetic differences between individuals may be a contributing factor. The purpose of this work was to screen the entire genome for genetic markers associated with chondromalacia.

Design

Genome-wide association (GWA) analyses were performed utilizing data from the Kaiser Permanente Research Board (KPRB) and the UK Biobank. Chondromalacia cases were identified based on electronic health records from KPRB and UK Biobank. GWA analyses from both cohorts were tested for chondromalacia using a logistic regression model adjusting for sex, height, weight, age of enrollment, and race/ethnicity using allele counts for single-nucleotide poly

SUBMITTER: Kim SK 

PROVIDER: S-EPMC9459478 | biostudies-literature | 2022 Jul-Sep

REPOSITORIES: biostudies-literature