MRI-guided focal or integrated boost high dose rate brachytherapy for recurrent prostate cancer.

ABSTRACT:

Background and purpose

Locally recurrent prostate cancer after radiotherapy merits an effective salvage strategy that mitigates the risk of adverse events. We report outcomes of a cohort enrolled across two institutions investigating MRI-guided tumor-targeted salvage high dose rate brachytherapy (HDR-BT).

Materials and methods

Analysis of a prospective cohort of 88 patients treated across two institutions with MRI-guided salvage HDR-BT to visible local recurrence after radiotherapy (RT). Tumor target dose ranged from 22-26 Gy, using either an integrated boost (ibBT) or focal technique (fBT), delivered in two implants over a median of 7 days. Outcome metrics included cancer control and toxicity (CTCAE). Quality of life (QoL-EPIC) was analyzed in a subset.

Results

At a

SUBMITTER: Menard C 

PROVIDER: S-EPMC9459480 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature