Prognostic factors in Japanese men with high-Gleason metastatic castration-resistant prostate cancer.

ABSTRACT:

Background

Several therapeutic agents are available for metastatic castration-resistant prostate cancer (CRPC). However, prognosis is still not well developed. The Gleason score (GS) is a prognostic factor available for patients with metastatic CRPC. GSs ranging from 6 to 10 and GSs ≥8 are usually categorized as single prognostic factors. In this study, we evaluated the prognosis of high-GS metastatic CRPC in Japanese men.

Methods

Overall, 105 patients with metastatic CRPC with a GS ≥8 were retrospectively analyzed. Multivariate analyses of patient age, GS, and Eastern Cooperative Oncology Group performance status (ECOG-PS) were performed using Cox proportional hazards analysis to predict overall survival (OS).

Results

GS 8 had all Gleason patterns of 4+4. Thirty pati

SUBMITTER: Nishimoto M 

PROVIDER: S-EPMC9459578 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature