Prognostic implications of cellular senescence in resected non-small cell lung cancer.

ABSTRACT:

Background

Cure and long-term survival for non-small cell lung cancer (NSCLC) remains hard to achieve. Cellular senescence, an emerging hallmark of cancer, is considered as an endogenous tumor suppressor mechanism. However, senescent cancer cells can paradoxically affect the surrounding tumor microenvironment (TME), ultimately leading to cancer relapse and metastasis. As such, the role of cellular senescence in cancer is highly controversial.

Methods

In 155 formalin-fixed paraffin-embedded (FFPE) samples from surgically resected NSCLC patients with pathological tumor-node-metastasis (pTNM) stages I-IV (8th edition), cellular senescence was assessed using a combination of four immunohistochemical senescence markers, i.e., lipofuscin, p16^INK4a, p21^WAF1/Cip1

SUBMITTER: Domen A 

PROVIDER: S-EPMC9459607 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature