Exploration of metabolic responses towards hypoxia mimetic DMOG in cancer cells by using untargeted metabolomics.

ABSTRACT: Hypoxia is considered as one of the most crucial elements of tumor microenvironment. The hypoxia inducible transcription factors (HIF-1/2) are used by the cancer cells to adapt hypoxic microenvironment through regulating the expression of various target genes, including metabolic enzymes. Dimethyloxalylglycine (DMOG), a hypoxic mimetic used for HIF stabilisation in cell and animal models, also demonstrates multiple metabolic effects. In past, it was shown that in cancer cells, DMOG treatment alters mitochondrial ATP production, glycolysis, respiration etc. However, a global landscape of metabolic level alteration in cancer cells during DMOG treatment is still not established. In the current work, the metabolic landscape of cancer cells during DMOG treatment is explored by using untargeted

SUBMITTER: Imran Khan M 

PROVIDER: S-EPMC9460158 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature