Comparing and Quantifying the Efficiency of Cocrystal Screening Methods for Praziquantel.

ABSTRACT: Pharmaceutical cocrystals are highly interesting due to their effect on physicochemical properties and their role in separation technologies, particularly for chiral molecules. Detection of new cocrystals is a challenge, and robust screening methods are required. As numerous techniques exist that differ in their crystallization mechanisms, their efficiencies depend on the coformers investigated. The most important parameters characterizing the methods are the (a) screenable coformer fraction, (b) coformer success rate, (c) ability to give several cocrystals per successful coformer, (d) identification of new stable phases, and (e) experimental convenience. Based on these parameters, we compare and quantify the performance of three methods: liquid-assisted grinding, solvent evaporation, and

SUBMITTER: Charpentier MD 

PROVIDER: S-EPMC9460446 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature