Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System.

ABSTRACT: Conventional oral formulations are mainly absorbed in the small intestine. This limits their use in the treatment of some diseases associated with the colon, where the drug has to act topically at the inflammation site. This paved the way for the development of a smart colonic drug delivery system, thereby improving the therapeutic efficacy, reducing the dosing frequency and potential side effects, as well as improving patient acceptance, especially in cases where enemas or other topical preparations may not be effective alone in treating the inflammation. In healthy individuals, it takes an oral medication delivery system about 5 to 6 h to reach the colon. A colonic drug delivery system should delay or prohibit the medication release during these five to six hours while permitting its rel

SUBMITTER: Bayan MF 

PROVIDER: S-EPMC9460644 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature