Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism.

ABSTRACT: Synaptic impairment might precede neuronal degeneration in Parkinson's disease. However, the intimate mechanisms altering synaptic function by the accumulation of presynaptic α-synuclein in striatal dopaminergic terminals before dopaminergic death occurs, have not been elucidated. Our aim is to unravel the sequence of synaptic functional and structural changes preceding symptomatic dopaminergic cell death. As such, we evaluated the temporal sequence of functional and structural changes at striatal synapses before parkinsonian motor features appear in a rat model of progressive dopaminergic death induced by overexpression of the human mutated A53T α-synuclein in the substantia nigra pars compacta, a protein transported to these synapses. Sequential window acquisition of all theoretical mass

SUBMITTER: Merino-Galan L 

PROVIDER: S-EPMC9460676 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature