Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study.

ABSTRACT: The multi-attribute method (MAM) was conceived as a single assay to potentially replace multiple single-attribute assays that have long been used in process development and quality control (QC) for protein therapeutics. MAM is rooted in traditional peptide mapping methods; it leverages mass spectrometry (MS) detection for confident identification and quantitation of many types of protein attributes that may be targeted for monitoring. While MAM has been widely explored across the industry, it has yet to gain a strong foothold within QC laboratories as a replacement method for established orthogonal platforms. Members of the MAM consortium recently undertook an interlaboratory study to evaluate the industry-wide status of MAM. Here we present the results of this study as they pertain to the

SUBMITTER: Mouchahoir T 

PROVIDER: S-EPMC9460773 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature