Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China.

ABSTRACT: Alcohol consumption has been associated with the risk of mild cognitive impairment (MCI) in observational studies. The result is inconsistent and whether the association is causal remains unknown. To examine the causal effect of alcohol consumption on MCI in rural China, this study used a cross-sectional dataset that included 1966 observations collected in rural China, of which 235 observations' genotyping were collected. All participants accepted the MCI evaluation using Mini-Cog and were asked about the participants' alcohol consumption behavior. The causal effect of alcohol consumption on MCI was investigated by Mendelian randomization (MR) of genetic variation in the aldehyde dehydrogenase 2 (ALDH2 rs671) gene. The risk of MCI in Chinese rural areas was 43%. Alcohol consumption

SUBMITTER: Cui Y 

PROVIDER: S-EPMC9460868 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature