Combination strategies to optimize the efficacy of chimeric antigen receptor T cell therapy in haematological malignancies.

ABSTRACT: Chimeric antigen receptor (CAR) T cell therapy has revolutionized the therapeutic landscape of haematological malignancies. However, resistance and relapse remain prominent limitations, and they are related to the limited persistence and efficacy of CAR T cells, downregulation or loss of tumour antigens, intrinsic resistance of tumours to death signalling, and immune suppressive microenvironment. Rational combined modality treatments are regarded as a promising strategy to further unlock the antitumor potential of CAR T cell therapy, which can be applied before CAR T cell infusion as a conditioning regimen or in ex vivo culture settings as well as concomitant with or after CAR T cell infusion. In this review, we summarize the combinatorial strategies, including chemotherapy, radioth

SUBMITTER: Xiao X 

PROVIDER: S-EPMC9460961 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature