Metformin is Associated with Reduced COVID-19 Severity in Patients with Prediabetes.

ABSTRACT:

Background

With the continuing COVID-19 pandemic, identifying medications that improve COVID-19 outcomes is crucial. Studies suggest that use of metformin, an oral antihyperglycemic, is associated with reduced COVID-19 severity in individuals with diabetes compared to other antihyperglycemic medications. Some patients without diabetes, including those with polycystic ovary syndrome (PCOS) and prediabetes, are prescribed metformin for off-label use, which provides an opportunity to further investigate the effect of metformin on COVID-19.

Participants

In this observational, retrospective analysis, we leveraged the harmonized electronic health record data from 53 hospitals to construct cohorts of COVID-19 positive, metformin users without diabetes and propensity-weighted contro

SUBMITTER: Chan LE 

PROVIDER: S-EPMC9460973 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature