Construction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis.

ABSTRACT:

Background

Thyroid eye disease (TED) is the most common orbital pathology that occurs in up to 50% of patients with Graves' disease. Herein, we aimed at discovering the possible hub genes and pathways involved in TED based on bioinformatical approaches.

Results

The GSE105149 and GSE58331 datasets were downloaded from the Gene Expression Omnibus (GEO) database and merged for identifying TED-associated modules by weighted gene coexpression network analysis (WGCNA) and local maximal quasi-clique merger (lmQCM) analysis. EdgeR was run to screen differentially expressed genes (DEGs). Transcription factor (TF), microRNA (miR) and drug prediction analyses were performed using ToppGene suite. Function enrichment analysis was used to investigate the biological function of genes. Prot

SUBMITTER: Hu J 

PROVIDER: S-EPMC9461120 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature