Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank.

ABSTRACT:

Background

Grip strength is a widely used and well-validated measure of overall health that is increasingly understood to index risk for psychiatric illness and neurodegeneration in older adults. However, existing work has not examined how grip strength relates to a comprehensive set of mental health outcomes, which can detect early signs of cognitive decline. Furthermore, whether brain structure mediates associations between grip strength and cognition remains unknown.

Methods

Based on cross-sectional and longitudinal data from over 40,000 participants in the UK Biobank, this study investigated the behavioral and neural correlates of handgrip strength using a linear mixed effect model and mediation analysis.

Results

In cross-sectional analysis, we found that greater

SUBMITTER: Jiang R 

PROVIDER: S-EPMC9461129 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature