Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study.

ABSTRACT:

Background

Chronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet.

Methods

The Olink Target 96 Inflammation panel was measured in baseline serum samples (collected 07/2000-06/2002) of 1782 older adults from a German, population-based cohort study in a case-cohort design. Logistic regression models were used to assess the associations of biomarkers with all-cause dementia, Alzheimer's disease, and vascular dementia incidence.

Results

During 17 years of follow-up, 504 participants were diagnosed with dementia, including 163 Alzheimer's disease and 195 vascular dementia cases. After correction for multiple testing, 58 out o

SUBMITTER: Trares K 

PROVIDER: S-EPMC9461133 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature