Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.

ABSTRACT:

Background

The molecular drivers of early sporadic Parkinson's disease (PD) remain unclear, and the presence of widespread end stage pathology in late disease masks the distinction between primary or causal disease-specific events and late secondary consequences in stressed or dying cells. However, early and mid-stage Parkinson's brains (Braak stages 3 and 4) exhibit alpha-synuclein inclusions and neuronal loss along a regional gradient of severity, from unaffected-mild-moderate-severe. Here, we exploited this spatial pathological gradient to investigate the molecular drivers of sporadic PD.

Methods

We combined high precision tissue sampling with unbiased large-scale profiling of protein expression across 9 brain regions in Braak stage 3 and 4 PD brains, and controls, and ve

SUBMITTER: Toomey CE 

PROVIDER: S-EPMC9461181 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature