Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19.

ABSTRACT:

Background

Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility.

Methods

One hundred and eighty patients diagnosed to have COVID-19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21-29 ng/mL, deficient at <20 ng/mL.

Results

Ninety-four pati

SUBMITTER: Zeidan NMS 

PROVIDER: S-EPMC9461391 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature