The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media.

ABSTRACT: Otitis media (OM), the most common disease of childhood, is typically characterized by bacterial infection of the middle ear (ME). Prominent features of OM include hyperplasia of the ME mucosa, which transforms from a monolayer of simple squamous epithelium with minimal stroma into a full-thickness respiratory epithelium in 2-3 days after infection. Analysis of the murine ME transcriptome during OM showed down-regulation of the tumor suppressor gene Ecrg4 that was temporally related to mucosal hyperplasia and identified stromal cells as the primary ECRG4 source. The reduction in Ecrg4 gene expression coincided with the cleavage of ECRG4 protein to release an extracellular fragment, augurin. The duration of mucosal hyperplasia during OM was greater in Ecrg4 ^-/-<

SUBMITTER: Kurabi A 

PROVIDER: S-EPMC9461705 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature