Enhanced toxicity to chemoradiation in a patient with Anti-Jo-1-antisynthetase syndrome.

ABSTRACT: Appropriate counseling of patients with autoimmune connective tissue disorders (ACTDs) is often challenging for radiation oncologists, especially regarding anticipated side-effects of radiation treatment. These patients can have highly variable and unpredictable sequelae from radiation therapy, and the uncertainty builds when radiation is convoluted by the addition of concurrent chemotherapy. While many patients may experience a mild intensification of toxicity above what is expected, some patients experience much more severe toxicity. These patients become critical learning cases, enabling a better understanding of the delicate and complex ways in which radiation response is altered in the context of ACTDs while allowing other patients with similar ACTD profiles to benefit from past exper

SUBMITTER: Valle L 

PROVIDER: S-EPMC9461731 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature