Munich atopy prediction study (MAPS): protocol for a prospective birth cohort addressing clinical and molecular risk factors for atopic dermatitis in early childhood

ABSTRACT:

Introduction

The pathogenesis of atopic diseases is highly complex, and the exact mechanisms leading to atopic dermatitis (AD) onset in infants remain mostly enigmatic. In addition to an interdependent network of components of skin development in young age and skin barrier dysfunction underlying AD development that is only partially understood, a complex interplay between environmental factors and lifestyle habits with skin barrier and immune dysregulation is suspected to contribute to AD onset. This study aims to comprehensively evaluate individual microbiome and immune responses in the context of environmental determinants related the risk of developing AD in the first 4 years of a child’s life.

Methods and analyses

The ‘Munich Atopic Prediction Study’ is a comprehensiv

SUBMITTER: Preis S 

PROVIDER: S-EPMC9462110 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature