Level of sedation in critically ill adult patients: a protocol for a systematic review with meta-analysis and trial sequential analysis

ABSTRACT:

Introduction

It is standard of care to provide sedation to critically ill patients to reduce anxiety, discomfort and promote tolerance of mechanical ventilation. Given that sedatives can have differing effects based on a variety of patient and pharmacological characteristics, treatment approaches are largely based on targeting the level of sedation. The benefits of differing levels of sedation must be balanced against potential adverse effects including haemodynamic instability, causing delirium, delaying awakening and prolonging the time of mechanical ventilation and intensive care stay. This systematic review with meta-analysis aims to investigate the current evidence and compare the effects of differing sedation levels in adult critically ill patients.

Methods and analyses<

SUBMITTER: Ceric A 

PROVIDER: S-EPMC9462111 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature