Glucocorticoid receptor expression in patients with cardiac arrest in the early period after the return of spontaneous circulation: a prospective observational single-centre study

ABSTRACT:

Objectives

Rapid changes in glucocorticoid (GC) levels and adrenal insufficiency are related to the development of post-cardiac arrest (CA) syndrome. However, GC receptor (GR) expression changes have not been studied. Hence, this study aimed to investigate the association of early changes in GR expression and prognosis and immune response in patients who experienced CA.

Design

Prospective observational study.

Setting

Emergency department.

Participants

Patients (85) in the early period of return of spontaneous circulation (ROSC) after CA were admitted between October 2018 and October 2019. After a physical examination, age-matched and sex-matched healthy individuals (40) were recruited for the control group.

Primary and secondary outcome measures

SUBMITTER: Yu Y 

PROVIDER: S-EPMC9462114 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature