Significance of pancreatic duodenal homeobox-1 (PDX-1) genetic polymorphism in insulin secretion in Japanese patients with type 2 diabetes.

ABSTRACT:

Introduction

Pancreatic and duodenal homeobox factor-1 (PDX-1) is an imperative gene for insulin secretion in maturity-onset diabetes of the young 4. PDX-1 gene polymorphism was associated with lower first-phase insulin secretion in a genome-wide association study of intravenous glucose tolerance test. It was not associated with type 2 diabetes risk and insulin secretion in a genome-wide oral glucose tolerance test study. However, there have been no reports of overt type 2 diabetes and insulin resistance evaluation using a glucose clamp. We investigated PDX-1 polymorphism, insulin secretion, and insulin resistance in overt type 2 diabetes.

Research design and methods

We performed a meal tolerance test (MTT) and hyperinsulinemic-euglycemic clamping on 63

SUBMITTER: Okura T 

PROVIDER: S-EPMC9462127 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature