Ethyl (3S)-3-[(3aR,5R,6S,6aR)-6-hy­droxy-2,2-di­methyl­tetra­hydro­furo[4,5-d][1,3]dioxol-5-yl]-3-{(3S)-3-[(3aR,5R,6S,6aR)-6-hy­droxy-2,2-di­methyl­tetra­hydro­furo[4,5-d][1,3]dioxol-5-yl]-5-oxoisoxazolidin-2-yl}propano­ate chloro­form monosolvate

ABSTRACT: The Flack and Watkin 2AD plot based on 1941 acentric Friedel pairs for the title chloro­form solvate shows that the observed intensity differences for Friedel opposites are dominated by random and systematic errors, erasing information about resonant scattering. The title compound, C22H33NO12·CHCl3, was obtained as a product of a double aza-Michael addition of hydroxyl­amine on a Chiron with a known absolute configuration. The enanti­opure compound crystallized as a chloro­form solvate, in space group P1, and diffraction data were collected at room temperature with Ag Kα radiation. The Flack parameter refined to x = −0.01 (16); however, the Flack and Watkin 2AD plot clearly shows that differences between Friedel opposites (the D component of the plot) do not carry any reliable information

SUBMITTER: Amaro Hernandez A 

PROVIDER: S-EPMC9462232 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature