Novel insight into the aetiology of rheumatoid arthritis gained by a cross-tissue transcriptome-wide association study.

ABSTRACT:

Background

Although genome-wide association studies (GWASs) have identified more than 100 loci associated with rheumatoid arthritis (RA) susceptibility, the causal genes and biological mechanisms remain largely unknown.

Methods

A cross-tissue transcriptome-wide association study (TWAS) using the unified test for molecular signaturestool was performed to integrate GWAS summary statistics from 58 284 individuals (14 361 RA cases and 43 923 controls) with gene-expression matrix in the Genotype-Tissue Expression project. Subsequently, a single tissue by using FUSION software was conducted to validate the significant associations. We also compared the TWAS with different gene-based methodologies, including Summary Data Based Mendelian Randomization (SMR) and Multimarker Analysis

SUBMITTER: Ni J 

PROVIDER: S-EPMC9462377 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature