Inverse radiotherapy planning based on bioeffect modelling for locally advanced left-sided breast cancer.

ABSTRACT:

Background and purpose

Treatment planning of radiotherapy (RT) for left-sided breast cancer is a challenging case. Several competing concerns are incorporated at present through protocol-defined dose-volume constraints, e.g. cardiac exposure and target coverage. Such constraints are limited by neglecting patient-specific risk factors (RFs). We propose an alternative RT planning method based solely on bioeffect models to minimize the estimated risks of breast cancer recurrence (BCR) and radiation-induced mortality endpoints considering patient-specific factors.

Methods and materials

Thirty-nine patients with left-sided breast cancer treated with comprehensive post-lumpectomy loco-regional conformal RT were included. An in-house particle swarm optimization (PSO) engine was use

SUBMITTER: Stick LB 

PROVIDER: S-EPMC9462462 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature