Paclitaxel-induced diffuse scleroderma with possible scleroderma-renal crisis: a case report and literature review of taxanes-induced scleroderma.

ABSTRACT:

Introduction/objectives

Scleroderma is a rare complication in taxanes therapy. Although individual cases of taxanes-induced scleroderma have been reported, the clinical manifestation and treatment outcomes were reviewed and summarized rarely. This study reported a patient who developed diffuse scleroderma and possible scleroderma renal crisis after paclitaxel therapy for ureter cancer.

Method

A PubMed literature review on published cases of taxanes-induced scleroderma up until April 2022 was included for analysis.

Results

The search identified 27 patients with adequate information for analysis. Of the 28 patients, including the one presented here, 22 were female. Peripheral edema was the most common symptom in all but one patient, and often accompanied by erythema in

SUBMITTER: Ketpueak T 

PROVIDER: S-EPMC9462648 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature