Examination on the risk factors of cholangiocarcinoma: A Mendelian randomization study.

ABSTRACT: Background: Several risk factors have been identified for CCA, however, whether such associations were causal remains unknown. Methods: Mendelian randomization (MR) has been applied to examine the causal relationship between 26 putative risk factors and CCA. The genetic variants for each risk factor were extracted from their corresponding genome-wide association study (GWAS) if they reached the genome-wide significance (p-value < 5 × 10^-8). The genetic associations with CCA were obtained from the publicly available GWAS with the largest sample size. Mainly, inverse-variance weighted (IVW) has been adopted to estimate the causal effect on CCA. Both multivariable and mediation MR analyses were carried out to detect independent factors. Results: Three pu

SUBMITTER: Chen L 

PROVIDER: S-EPMC9462706 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature