Colorectal cancers with a residual adenoma component: Clinicopathologic features and KRAS mutation.

ABSTRACT:

Background/aim

Colorectal cancer is well known for its "adenoma-carcinoma" sequential carcinogenesis. Some colorectal cancers demonstrate a residual adenoma component during progression from adenoma to invasive carcinoma. However, the clinicopathological significance of residual adenoma component remains unclear. In this study, we aimed to investigate the clinicopathologic and molecular characteristics including the KRAS mutation in colorectal cancers containing a residual adenoma component.

Materials and methods

In this study, 498 surgically resected colorectal cancer patients were enrolled. Their detailed clinicopathologic features and results of molecular study including KRAS mutation test and microsatellite instability were analyzed.

Results

A residual adenoma com

SUBMITTER: Lee HW 

PROVIDER: S-EPMC9462729 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature