A multi-objective based clustering for inferring BCR clonal lineages from high-throughput B cell repertoire data.

ABSTRACT: The adaptive B cell response is driven by the expansion, somatic hypermutation, and selection of B cell clonal lineages. A high number of clonal lineages in a B cell population indicates a highly diverse repertoire, while clonal size distribution and sequence diversity reflect antigen selective pressure. Identifying clonal lineages is fundamental to many repertoire studies, including repertoire comparisons, clonal tracking, and statistical analysis. Several methods have been developed to group sequences from high-throughput B cell repertoire data. Current methods use clustering algorithms to group clonally-related sequences based on their similarities or distances. Such approaches create groups by optimizing a single objective that typically minimizes intra-clonal distances. However, optim

SUBMITTER: Abdollahi N 

PROVIDER: S-EPMC9462827 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature