Defining HPV-specific B cell responses in patients with head and neck cancer.

ABSTRACT: Tumours often contain B cells and plasma cells but the antigen specificity of these intratumoral B cells is not well understood^1-8. Here we show that human papillomavirus (HPV)-specific B cell responses are detectable in samples from patients with HPV-positive head and neck cancers, with active production of HPV-specific IgG antibodies in situ. HPV-specific antibody secreting cells (ASCs) were present in the tumour microenvironment, with minimal bystander recruitment of influenza-specific cells, suggesting a localized and antigen-specific ASC response. HPV-specific ASC responses correlated with titres of plasma IgG and were directed against the HPV proteins E2, E6 and E7, with the most dominant response against E2. Using intratumoral B cells and plasma cells, we generated severa

SUBMITTER: Wieland A 

PROVIDER: S-EPMC9462833 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature